NIMG-14. RADIOLOGIC ASSESSMENT OF BRAIN METASTASES UNDERGOING LASER INTERSTITIAL THERMAL THERAPY (LITT)
نویسندگان
چکیده
Abstract BACKGROUND Laser Interstitial Thermal Therapy (LITT) is a novel treatment for brain metastases (BMs), and data regarding radiologic changes long-term efficacy sparse. This study explored volumetric in responding non-responding BMs their associations with lesion-specific progression-free survival (PFS-L). METHODS Patients treated LITT were retrospectively enrolled. 3D volumes-of-interest of the contrast-enhancing BM tissue (CE) on pre-, post-LITT, follow-up MRI scans obtained. followed until progression or censoring. PFS-L was determined using modified RANO criteria to assess each lesion. RESULTS Thirty-one (from 30 patients) preliminarily analyzed. 2 had no scans. Median 29 248 days (range 28-2200). time response 430 (responders n=7/29), median 176 (progressive disease n=7/29). Pre-LITT CE volume predictor (p=0.001), BMs> 2.5 cc being 14 times more likely undergo progression. Differences age primary tumor site did not impact PFS-L, whereas tended be longer females (p=0.059), frontal deep grey matter (p=0.11). Post-LITT higher than pre-LITT (p< 0.0001, increase 59%), significant differences among responders, stable disease, progressive disease. In BM, shrinkage over described by an exponential decay (R2 ranging 0.92-1.0 half-life 16.55-204 days). All showed pooled R2=0.88 half-life=75.6 days. CONCLUSIONS Our suggest that smaller may have improved outcomes from treatment. volumes early post-procedural scans, possibly due both inflammatory thermal damage. The characterization across lesions useful detection at risk
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ژورنال
عنوان ژورنال: Neuro-oncology
سال: 2022
ISSN: ['1523-5866', '1522-8517']
DOI: https://doi.org/10.1093/neuonc/noac209.632